In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 54608-52-5, name is 2-Hydrazinopyrazine belongs to pyrazines compound, it is a common compound, a new synthetic route is introduced below. name: 2-Hydrazinopyrazine
Step B: Preparation of (la/?,5a/?)-2-(Pyrazin-2-yl)-la,2,5,5a-tetrahydro-lH-2,3- diaza-cyclopropa[a]pentalene-4-carboxylic Acid Ethyl Ester. Method CTo a stirred suspension of 2-ethoxy-2-oxo-l-((lR,5R)-2-oxobicyclo[3.1.0]hexan-3- ylidene)ethanolate (300 mg, 1.28 mmol) in ethanol (5 mL) was added 2-hydrazinylpyrazine (141 mg, 1.28 mmol) followed by 6 N HQ (0.5 mL, 3.0 mmol). The reaction was stirred overnight at room temperature. The reaction was diluted with H20 and extracted with DCM. The combined organic phases were washed with H20, dried over MgS04, and concentrated. Purification by silica gel flash chromatography gave the title compound (150 mg). LCMS m/z = 271.2 [M+H]+; lU NMR (400 MHz, CDC13) delta ppm 0.47 (td, = 4.7 and 3.4 Hz, 1H), 1.22-1.28 (m, 1H), 1.39 (t, = 7.1 Hz, 3H), 2.26-2.30 (m, 1H), 2.77-2.82 (m, 1H), 2.87 (d, = 16.6 Hz, 1H), 2.98 (dd, / = 16.6 and 6.3 Hz, 1H), 4.40 (q, = 7.1 Hz, 2H), 8.40 (dd, / = 2.6 and 1.5 Hz, 1H), 8.51 (d, = 2.5 Hz, 1H), 9.39 (d, = 1.3 Hz, 1H).
The synthetic route of 54608-52-5 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; ARENA PHARMACEUTICALS, INC.; THATTE, Jayant; BLACKBURN, Anthony C.; HAN, Sangdon; JONES, Robert M.; JUNG, Jae-Kyu; MONTALBAN, Anthony Garrido; PAL, Biman B.; RUETER, Jaimie Karyn; STRAH-PLEYNET, Sonja; THORESEN, Lars; XIONG, Yifeng; YUE, Dawei; ZHU, Xiuwen; WO2012/116279; (2012); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem