Synthetic Route of 89464-87-9, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 89464-87-9 as follows.
(i) 4-Dimethylaminopyridine (0.1 g) was added to a solution of 2-chloropyridine-3-sulphonyl chloride (1.06 g), 2-amino-3-methoxy-5-methylpyrazine (0.695 g) and pyridine (0.424 ml) in dichloromethane (5 ml) and the mixture was stirred at ambient temperature for 18 hours. The solution was then transferred to a silica gel Mega Bond Elut column. Elution with 0-40% ethyl acetate/hexane gave 2-chloro-N-(3-methoxy-5-methylpyrazin-2-yl)pyridine-3-sulphonamide (0.47 g) as an oil; 1 H NMR (d6 -DMSO): 2.3 (s, 3 H), 3.9 (s, 3 H), 7.5 (s, 1 H), 7.65 (dd, 1 H), 8.45 (dd, 1 H), 8.7 (dd, 1 H); mass spectrum (+ve CI): 315 (M+H)+.
According to the analysis of related databases, 89464-87-9, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Zeneca Limited; US5866568; (1999); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem