5521-55-1, name is 5-Methylpyrazine-2-carboxylic acid, belongs to pyrazines compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Safety of 5-Methylpyrazine-2-carboxylic acid
To a stirred suspension of 5-methyl-pyrazine-2-carboxylic acid (25 gm, 181 mmol) in 540mL THF at room temperature under nitrogen was addedDIEA (31.7 mL, 181 mmol) resulting in a brown solu- tion. Diphenyl phosphoryl azide (39.2 mL, 181 mmol)then was added dropwise as a solution in 50 mL THFover 1 hour behind a blast shield. The reaction wasallowed to stir overnight. The reaction then wasrotoevaporated to a small volume at room temperatureand partitioned between Et2O (1 L) and H20 (1 L) .The H2O layer was back extracted with 2 x 250 mLEt2O, and the combined organics washed 2 x 1 L withsaturated sodium bicarbonate. The organics weredried (MgSO4) , filtered and concentrated to a solidmass which was triturated with Et20 to give theproduct as a yellow solid (15 gm, 50%). Purercompound could be isolated by taking 1 gm of thecrude product in 20 mL of Et2O and treating with 1-2gm of decolorizing carbon at room temperature for afew minutes. After filtration and concentration,this material was homogeneous by TLC in EtOAc andpure white. The recovery was typically 65%.
The synthetic route of 5521-55-1 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; ICOS CORPORATION; WO2006/12308; (2006); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem