In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 113305-94-5 as follows. Recommanded Product: 5-Aminopyrazine-2-carbonitrile
Into a flask, purged with an inertatmosphere of nitrogen, was placed 5-aminopyrazine-2-carbonitrile (0.69 ml, 8.33mmol) and EtOH (36.2 ml). To this was added 2-bromo-1 ,1-diethoxyethane (2.58 ml, 16.6 mmol) and HBr in water (6.59 mL, 58.3 mmol). The mixture was warmed at 85C for 4 h. Upon completion, the reaction was diluted with EtOAc (50 mL), cooled to 0C, and slowly quenched with satd. aq. NaHCO3 until the pH was adjusted to 9. Theresulting solution was extracted with EtOAc (3x), and the organic layers were combined and dried over anhyd. Na2SO4. The solid was filtered, and the filtrate was concentrated in vacuo to dryness. The crude mixture was triturated with DCM:hexanes (1:1). The liquid was decanted and the solid was dried to afford the title compound.
According to the analysis of related databases, 113305-94-5, the application of this compound in the production field has become more and more popular.
Reference:
Patent; MERCK SHARP & DOHME CORP.; GARFUNKLE, Joie; ORNOSKI, Olga; PARKER, Dann, L., Jr.; RAGHAVAN, Subharekha; XU, Libo; YANG, Zhiqiang; (96 pag.)WO2016/191335; (2016); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem