55557-52-3, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 55557-52-3 as follows.
The 3 – chloro -2 – cyanopyrazine (2.24 g 1.6 eq), 4 – amino -2 – pyrimidine formic acid (1.39 g 1 eq) and potassium carbonate (4.1 g 3 eq) solution 20 mLDMF in, stirring and heating to 60 C, reaction 5 h, cooling to room temperature, filter, solution (DCM/MeOH=20:1) for refining, yellow solid product to be 1.73 g (yield: 71%).
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 55557-52-3, and friends who are interested can also refer to it.
Reference:
Patent; Jiangxi Runze Pharmaceutical Co., Ltd.; Liao Niansheng; Zou Mingming; Hu Xiande; Sui Rongchun; Xu Man; (14 pag.)CN108689997; (2018); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem