Continuously updated synthesis method about 957344-74-0

The synthetic route of 957344-74-0 has been constantly updated, and we look forward to future research findings.

Related Products of 957344-74-0,Some common heterocyclic compound, 957344-74-0, name is 5,8-Dibromoimidazo[1,2-a]pyrazine, molecular formula is C6H3Br2N3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Step 2 (5-Bromo-imidazo[l,2-a]pyrazin-8-yl)-[4-(l-methyl-piperidin-4-ylmethoxy)-phenyl] -amine[00319] To a solution of 5,8-dibromo-imidazo[l,2-a]pyrazme (0.100g, 0.36mmol) in isopropanol (5mL) are added l,4-diazabicyclo[2,2,2]octane (DABCO) (0.036mL, 0 36mmol) and 4-(l- methyl-pipe?dm-4-ylmethoxy)-phenylamme (79 6mg, 0 36mmol) The reaction mixture is stirred at9O0C overnight The solvent is evaporated and the residue chromatographed on silica gel column elutmg with 97 3 followed by 94 6 and 90 10 DCM MeOH The title compound is obtained as a solid(20mg, 13%) LCMS Rt 2 30mm (94%), m/z (APCI) 417

The synthetic route of 957344-74-0 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; GALAPAGOS N.V.; WO2007/131991; (2007); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem