Some common heterocyclic compound, 6905-47-1, name is 2-Amino-6-methoxypyrazine, molecular formula is C5H7N3O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Formula: C5H7N3O
2-Amino-6-methoxy-pyrazine (1.00 g, 8 mmol; CASNo. 6905-47-1 ) was dissolved in a mix of 1 :2 THF:MeCN (30 ml.), cooled to 0 0C, and treated with pyridine (0.664 g, 8.3 mmol) followed by the dropwise addition oi phenylchloroformate (1.3 g, 8.3 mmol) in THF (10 ml_). After stirring for 18 h, the resulting white solid was collected by filtration (1.3 g, 68%) and was used without further purification.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 6905-47-1, its application will become more common.
Reference:
Patent; PFIZER INC.; WO2009/127948; (2009); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem