Synthetic Route of 40262-73-5, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 40262-73-5, name is 6-(4-Morpholinyl)pyrazine-2-carboxylic acid, This compound has unique chemical properties. The synthetic route is as follows.
(b) To a suspension of 2.50 g of 6-(4-morpholinyl) pyrazine-2-carboxylic acid in 50 ml of tetrahydrofuran, 3.60 ml of triethylamine and 1.60 ml of pivaloyl chloride were added dropwise successively at 0 C. under stirring. After stirring for 1 hour at 0 C., 1.12 g of 5-amino-1H-tetrazole was added to the mixture, and the reaction mixture was stirred for 1 hour at room temperature, and then refluxed for 12 hours. The reaction mixture was evaporated, and water was added to the residue. The precipitate was collected by filtration, and recrystallized from a mixture of dimethylsulfoxide and methanol affording 1.74 g of the desired compound as yellow needles. The obtained crystal was consistent with that of (a).
The chemical industry reduces the impact on the environment during synthesis 6-(4-Morpholinyl)pyrazine-2-carboxylic acid. I believe this compound will play a more active role in future production and life.
Reference:
Patent; Hokuriku Pharmaceutical Co., Ltd.; US4792547; (1988); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem