In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 5910-89-4 as follows. Safety of 2,3-Dimethylpyrazine
A solution of 10.0 g (93.0 mmol) 2,3-dimethylpyrazine and 70.0 g (390 mmol) N-bromo- succinimide in 800 ml CCI4 is irradiated with a 250 Watt lamp at reflux temperature during 20 hours. After cooling the solution is filtered and the organic phase is washed with a 5% sodium thiosulfate solution and water. After evaporation of the organic phase, the residue is crystallised in ethanol to give 29.1 g (74%) of the title compound, m.p.: 167-1700C.
According to the analysis of related databases, 5910-89-4, the application of this compound in the production field has become more and more popular.
Reference:
Patent; SYNGENTA PARTICIPATIONS AG,; WO2007/20050; (2007); A2;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem