Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 25513-92-2, name is Ethyl 3-methylpyrazine-2-carboxylate, A new synthetic method of this compound is introduced below., Formula: C8H10N2O2
A mixture of 3-methyl-pyrazine-2-carboxylic acid ethyl ester (2.5 g, 15.04 mmol), N-bromosuccinimide also referred to herein as NBS (5.5 g, 30.8 mmol), and azobisisobutyronitrile also referred to herein as AIBN (0.12 g, 0.75 mmol) in carbon tetrachloride (50 ml) was stirred and refluxed for 48 h, cooled to room temperature, filtered and washed with CCI4. The filtrate was evaporated and the crude residue purified by FC chromatography eluting with 15% ethylacetate/ cyclohexane to give the desired product as a pale yellow solid (1 .64 g)1H-NMR (CDCI3): 8.71 (d, 1 H), 8.68 (d, 1 H), 5.1 (s, 2H), 4.58 (q, 2H), 1 .44 (t, 3H)
The synthetic route of 25513-92-2 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; BASF SE; REINGRUBER, Ruediger; KRAUS, Helmut; HUTZLER, Johannes; NEWTON, Trevor, William; WITSCHEL, Matthias; MOBERG, William, Karl; PARRA RAPADO, Liliana; BESONG, Gilbert; RACK, Michael; KLOET, Andree van der; SEITZ, Thomas; LERCHL, Jens; KREUZ, Klaus; GROSSMANN, Klaus; EVANS, Richard, Roger; WO2012/85265; (2012); A1;,
Pyrazine – Wikipedia,
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