Adding a certain compound to certain chemical reactions, such as: 5521-58-4, name is 5-Methylpyrazin-2-amine, belongs to Pyrazines compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 5521-58-4, 5521-58-4
DMF (2 drops) was added to a solution of3-{[(LS}1-methyl-2-(methyloxy)ethyl]oxy}-5- [(phenylmethyl)oxy]benzoic acid (6.0 g, 19.0 mmol) and oxalyl chloride (1.99 mL, 22.8 mmol) in DCM (40 mL) The mixture was stirred at ambient temperature for 2 hours and the DCM and excess oxalyl chloride evaporated in vacuo. The residual acid chloride was dissolved in DCM and added dropwise to 2-amino-5 methylpyrazine [Tett lett. 2002, 9287-90] (2.28 g, 19.8 mmol) and pyridine (2.56 mL, 38 mmol) in DCM (40 mL), at 0C. Stirred at ambient temperature for 24 hours. The DCM was evaporated in vacuo, and the residue partitioned between ethyl acetate (100 mL) and IN hydrochloric acid (50 mL). The ethyl acetate layer was washed sequentially with saturated aqueous sodium hydrogen carbonate (50 mL) and brine (50 mL), dried (MgS04), and evaporated in vacuo. The residue was chromatographed on silica, eluting with a gradient of 30-100% ethyl acetate in isohexane, to give the desired compound (7.6 g) ‘H NMR No. (CDC13): 1.32 (d, 3H), 2.55 (s, 3H), 3.40 (s, 3H), 3.50-3.62 (m, 2H), 4.60 (m, 1H), 5.10 (s, 2H), 6.75 (s, 1H), 7.09 (m, 1H), 7.13 (m, 1H), 7.32-7.46 (m, 5H), 8.13 (s, 1 H), 8.38 (s, 1H), 9.55 (s, 1H). m/z 408 (M+H)+
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 5-Methylpyrazin-2-amine, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2005/121110; (2005); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem