In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 356783-14-7 as follows. COA of Formula: C6H4Cl2N2O2
(a) In 20 mL of acetonitrile was dissolved 2.0 g of methyl 3,6-dichloro-2-pyrazinecarboxylate. After adding 2.8 g of potassium fluoride and 0.51 g of 18-crown-6-ether, the mixture thus obtained was heated under reflux for 9.5 hours in an atmosphere of nitrogen gas. After cooling, the solvent was removed under reduced pressure, and the residue was purified by silica gel chromatography [eluent: n-hexane:ethyl acetate=15:1] to obtain 1.1 g of methyl 3,6-difluoro-2-pyrazinecarboxylate as a colorless oily product. R (neat) cm-1: 1743 H-NMR (CDCl3) delta: 4.05(3H,s), 8.28(1H,dd,J=1.6 Hz, 8.4 Hz)
According to the analysis of related databases, 356783-14-7, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Toyama Chemical Co., Ltd.; US2003/130213; (2003); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem