These common heterocyclic compound, 1082843-70-6, name is 3,5-Dibromo-2-chloropyrazine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: 3,5-Dibromo-2-chloropyrazine
Add B1-a (2g, 7.34mmol) and ethanol (20mL) to a 50mL single-necked flask.Slowly add hydrazine hydrate (1.72g, 53.65mmol) in an ice bath.The suspension was stirred at 40 C for 3 hours. After the reaction is completed, the temperature is lowered to room temperature.A pale yellow solid precipitated out and was collected by filtration. The filter cake was washed with ethanol (5 mL).Drying gave the product B1-b (1 g, yield 60%) as a pale yellow solid.
The synthetic route of 3,5-Dibromo-2-chloropyrazine has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Shanghai Qingyu Pharmaceutical Technology Co., Ltd.; Zou Bin; Ma Shichao; Wang Xiang; Zhang Zhongguo; (61 pag.)CN110734436; (2020); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem