6863-73-6, name is 3-Chloropyrazin-2-amine, belongs to pyrazines compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Safety of 3-Chloropyrazin-2-amine
A mixture of bromoacetaldehyde diethyl acetal (29 ml,192.77 mmol) and 48% aqueous hydrogen bromide solution (7 ml)was stirred at reflux temperature for 1.5 h. After cooling back toroom temperature it was poured onto a suspension of sodiumhydrogen carbonate (14.50 g, 172.62 mmol) and 2-propanol(230 ml) and stirred until the gas evolution ceased. The formedprecipitate was filtered, then 2-amino-3-chloropyrazine (8) (7.51 g,58 mmol) was added to the filtrate and stirred at reflux temperaturefor 3 h. The reaction mixture was allowed to cool down toroom temperature, the resulting solid was collected by filtrationand washed with 2-propanol. The solid was partitioned betweenchloroform and 10% aqueous sodium hydrogen carbonate solution.The layers were separated and the aqueous layer was extractedwith chloroform (2). The combined organic layers were dried oversodium sulphate, filtered and concentrated under reduced pressure.The crude product was triturated with diisopropyl ether andfiltered to give the title compound (6.48 g)
The synthetic route of 6863-73-6 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Garamvoelgyi, Rita; Dobos, Judit; Sipos, Anna; Boros, Sandor; Illyes, Eszter; Baska, Ferenc; Kekesi, Laszlo; Szabadkai, Istvan; Szantai-Kis, Csaba; Keri, Gyoergy; Oerfi, Laszlo; European Journal of Medicinal Chemistry; vol. 108; (2016); p. 623 – 643;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem