Reference of 1458-18-0, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 1458-18-0 as follows.
The mixture of methyl 3-amino-5, 6-dichloropyrazine-2-carboxylate (0.5 g, 2.26 nMol) , 4, 4, 5, 5-tetramethyl-2- (5-methylfuran-2-yl) -1, 3, 2-dioxaborolane (0.71 g, 3.39 nMol) in dioxane (20 mL) was added Na 2CO 3 (0.94 g, 4.53 nMol) and Pd (dppf) Cl 2 (0.83 g, 1.13 nMol) at 100 . Then the mixture was stirred at this temperature for 2 h. LCMS showed the reaction was completed and purified with silica gel chromatography to give a desired product methyl 3-amino-6-chloro-5- (5-methylfuran-3-yl) pyrazine-2-carboxylate. LCMS: m/z (ESI) , [M+H] + = 268.4.
According to the analysis of related databases, 1458-18-0, the application of this compound in the production field has become more and more popular.