Application of 19745-07-4, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 19745-07-4 name is 2,5-Dichloropyrazine, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
Tris(dibenzylideneacetone)dipalladium(0) (0.123 g, 0.134 mmol), xantphos (0.300 g, 0.503 mmol), potassium carbonate (1 .18 g, 8.39 mmol) and 2-hydroxy-4-methoxy-3-m ethyl- 1 ,2- dihydropyrrol-5-one (0.480 g, 3.36 mmol) were stirred in 1 ,4-dioxane (20 mL), and the 2,5- dichloropyrazine (B, 0.500 g, 3.36 mmol) was added, the purple-red mixture then being warmed to around 80°C with stirring under a nitrogen atmosphere. After 5hr the mixture was cooled, then – – diluted with EtOAc (20ml) and water (10ml) and filtered through celite, washing through with further small portions of EtOAc and water. The organic phase was separated, the aqueous being further extracted with EtOAc (15ml). The organic extracts were combined, washed with water (10ml), dried over MgSO^ and filtered, and the filtrate adsorbed onto silica for chromatography to give a pale cream powder, 627mg (73percent).
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2,5-Dichloropyrazine, and friends who are interested can also refer to it.