These common heterocyclic compound, 23611-75-8, name is Methyl 6-chloropyrazine-2-carboxylate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Quality Control of Methyl 6-chloropyrazine-2-carboxylate
Step 3: Preparation of (6-chloropyrazin-2-yl)methanol. To a solution of methyl 6- chloropyrazine-2-carboxylate (2.0 g, 11.6 mmol) in water (20 mL) at 0 C was added NaBH4 (2.3 g, 58.0 mmol) portionwise. The reaction mixture was warmed to r.t. and stirred for 30 mm, followed by addition of satd. aq. K2C03 (40 mL) and EtOH (20 mL). The resulting mixture was stirred for another 1 hr and extracted with EA (2 x 20 mL). The combined organic layers were dried over anhydrous Na2SO4and concentrated and purified by standard methods to afford (6- chloropyrazin-2-yl)methanol. LC-MS: m/z 145.0 (M+H).
The synthetic route of Methyl 6-chloropyrazine-2-carboxylate has been constantly updated, and we look forward to future research findings.