Electric Literature of 33332-29-5,Some common heterocyclic compound, 33332-29-5, name is 2-Amino-5-chloropyrazine, molecular formula is C4H4ClN3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To a solution of 5-chloropyrazin-2-amine (25 g, 192.98 mmol) in DCM (250 mL) was added NBS (34.35 g, 192.98 mmol). The resulting mixture was stirred at 40 C for 1 hour. After cooling to room temperature and concentrated, water (200 mL) was added to give residue, extracted with EtOAc (150 mL x 2). The combined organic phase was washed with brine (150 mL), dried over Na2S04, filtered and concentrated to give the crude product. The crude product was purified by chromatography column on silica gel (EtOAc in PE = 0% to 15% to 30%) to give the product (31 g, 148.72 mmol, 77% yield) as a solid. ‘H NMR (DMSO-cL, 400MHz) 5H = 8.09 (s, 1H), 6.96 (s, 2H).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2-Amino-5-chloropyrazine, its application will become more common.