Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 87486-34-8, name is 3,5-Dibromo-1-methylpyrazin-2(1H)-one, A new synthetic method of this compound is introduced below., Recommanded Product: 87486-34-8
General procedure: To a solution of 2a-j (10 mmol, 1.0 eq) , 3,5-dibromo-1-methylpyrazin-2(1H)-one (2.95 g, 11 mmol, 1.1 eq) and DIEA (3.3 mL,20 mmol, 2.0 eq) in MeCN (20mL) was stirred at 80 °C for 5 hours. After cooling to room temperature, thesolvent was removed in vacuo, and the residue was purified using silica gelchromatography to give the title compounds, yield 72-85percent. methyl3-((6-bromo-4-methyl-3-oxo-3,4-dihydropyrazin-2-yl)amino)-4-methylpe ntanoate(4a): 1H NMR (400 MHz, DMSO-d6) delta 7.35 (d, 1H), 7.03 (s, 1H), 4.18? 4.07 (m, 1H), 3.54 (s, 3H), 3.36 (s, 3H), 2.69 ? 2.55 (m, 2H), 1.94 ? 1.80(m, 1H), 0.92 ? 0.76 (m, 6H). ESI-ms (m/z): 332.0 [M+H]+
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.