Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 4774-14-5, name is 2,6-Dichloropyrazine, A new synthetic method of this compound is introduced below., COA of Formula: C4H2Cl2N2
EXAMPLE 2 General Synthetic Procedure B Preparation of (6-Chloro-pyrazin-2-yl)-phenyl-amine To a solution of 2, 6-dichloropyrazine (5 g, 33.5 mmol, 1.0 equiv) in N- methylpyrrolidine (NMP) (11 ml) was added aniline (3.4 ml, 36. 9 mmol, 1.1 equiv). The mixture was then heated to 190C under microwave assisted heating (50 to 200 watts) for 20 minutes at atmospheric pressure. The reaction was cooled to room temperature and water (10 ml) and 1N NaOH (10 ml) were added. The mixture was extracted three times with diethyl ether. The combined organic layers were washed with water, brine, dried (MgS04) and concentrated under reduced pressure. The title compound was purified by flash chromatography on silica (100 g, Si02) eluted with 15% ethyl acetate-petrol to afford 3.1 g (45%); LCMS 3.74 min, m/z [M (35Cl) +H] + 206.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.