14508-49-7, name is 2-Chloropyrazine, belongs to pyrazines compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Computed Properties of C4H3ClN2
EXAMPLE 1; [5-(5-{4-[(2-Bromo-5-fluorophenyl)carbonyl1piperazin-l-yl}pyrazin-2-yl)-2i/-tetrazol-2- yl] acetic acid; Step 1 : fert-Butyl 4-(pyrazin-2-yl)piperazine- 1 -carboxylate; Into a 1 L flask equipped with a condenser and a magnetic stir bar was added 2- chloropyrazine (20.6 g, 180 mmol), tert-buXyl piperazine-1-carboxylate (33.5 g, 180 mmol), potassium carbonate (29.8 g, 216 mmol), dioxane (225 mL) and DMF (225 mL). The mixture was heated to 120 0C for 3 days. The mixture was cooled and poured into a 1 L separatory funnel containing brine (600 mL) and extracted with Et2O (3 x 200 mL). The combined organic layers were washed with brine, dried over MgSO4, filtered and concentrated under reduced pressure. Purification by column chromatography through silica gel, eluting with 50:50 hexanes:EtOAc to 20:80 hexanes:EtOAc as a gradient, afforded the title compound as a yellow solid.
The synthetic route of 14508-49-7 has been constantly updated, and we look forward to future research findings.