Synthetic Route of 486460-21-3, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 486460-21-3 as follows.
Example 22: Preparation of ((R)-3-(methoxyamino)-1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-4-(2,4,5-trifluorophenyl)butan-1-one (formula 16, R2=OMe) [Show Image] 6.0 g of compound of formula 15, 0.3 g 1-hydroxybenzotrizole hydrate (HOBt) and 4.7 g 3-(trifluoro-methyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine were dissolved in 40 mL of dry dichloromethane. To the clear solution 4.5 mL of N,N’-diisopropylcarbodiimide were added during stirring at 20 C. After addition, the reaction mixture was kept stirring for 2 hours at 23 C, followed by cooling the reaction mixture to 0 C for 2 hours. The precipitate was filtered-off and discarded. The filtrate was evaporated at 45 C and 5 mbar of final pressure, obtaining 12.0 g of crude product.
According to the analysis of related databases, 486460-21-3, the application of this compound in the production field has become more and more popular.