24241-18-7, A common compound: 24241-18-7, name is 2-Amino-3,5-dibromopyrazine, belongs to Pyrazines compound, it can change the direction of chemical reaction, and react with certain compounds to generate new functional products. A new synthetic method of this compound is introduced below.
To the reaction flask was added tetrahydrofuran (50 ml). trimethylsilylacetylene (580 mg, 5.9 mmol), triethylamine (1.2 g, 11.8 mmol), CuI (0.1 g), Pd(PPh3)4 (0.1 g) and the compound 3,5-dibromo-2-aminopyrazine 1a (1.0 g, 3.95 mmol) were reacted under nitrogen for 3 hours at room temperature.TLC showed the reaction was completed, 50ml of water was added and extracted with ethyl acetate (30mL) twice the aqueous phase, the organic phases are combined,Once, dried over anhydrous sodium sulfate washed with brine, and dried to give the crude product under reduced pressure using a rotary evaporator,Through the column to give the crude title compound 5a (0.5g, 18.5mmol), a yield of 47.1%
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Amino-3,5-dibromopyrazine, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Shanghai Huahuituo Pharmaceutical Technology Co., Ltd.; Zhejiang Huahai Pharmaceutical Co., Ltd.; Xu Xin; Zhang Tian; Li Yunfei; Wang Guan; Zhu Weibo; Li Qiang; Qu Minkai; Zhang Linli; Song Jinqian; Liu Lei; Chen Haiji; Liu Qiang; Wang Yijin; Ge Jian; (67 pag.)CN109535164; (2019); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem