Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 762240-92-6, name is 3-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine hydrochloride, A new synthetic method of this compound is introduced below., COA of Formula: C6H8ClF3N4
Into a 50 mL round-bottom flask was added 20 mL acetonitrile, followed by the addition of the phenyl-butyric acid derivative obtained in Example 46 (3.32 g, 0.01 mol) and triazolopyrazine hydrochloride (228 g, 0.01 mol). The temperature of the reaction mixture was cooled down to 0 C. in an ice-salt bath. 1-Hydroxylbenzotriazole (1.62 g, 0.012 mol) and 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride (2.29 g, 0.012 mol) were further added. 3 g Triethylamine was then added dropwise and the mixture was stirred at room temperature for 24 h. The reaction solution was washed with 3 X 20 mL distilled water. The obtained organic layers were collected and dried over anhydrous magnesium sulfate for 1 h. Then, the desiccant was filtered off and the resulting reactant was concentrated to 4.81 g. The yield was 95%. [alpha] D20=+22.2 (c 1.0, CHCl3). M.p. 188-191 C. IR (cm-1): 3374, 2897, 1686, 1635, 1519, 1368, 1164, 1128, 1016. 1H NMR (400 MHz, CDCl3) delta 7.187.05 (m, 1H), 7.02-6.85 (m, 1H), 5.31 (s, 1H), 5.154.76 (m, 2H), 4.433.78 (m, 5H), 2.982.92 (m, 2H), 2.712.61 (m, 2H), 1.36 (s, 9H). ESI-MS: 508.0 (M++1). HRMS Calcd. for: C21H23F6N5O3Na (M+Na)+ requires 530.1598, found 530.1604.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.