Related Products of 939412-86-9, The chemical industry reduces the impact on the environment during synthesis 939412-86-9, name is (3-Chloropyrazin-2-yl)methanamine hydrochloride, I believe this compound will play a more active role in future production and life.
To a stirred suspension of (3-chloropyrazin-2-yl)methanamine hydrochloride (0092) (500 mg, 2.78mmol) in ethyl acetate (10 mL) was added acetic anhydride (315 pL, 3.33 mmol) dropwise, followed by triethylamine (1.16 mL, 8.34 mmol). The mixture was stirred at room temperature for 1 h, and the solvent was removed under reduced pressure. The obtained residue was dissolved in methylene chloride (150 mL) and washed with saturated NaHC03 (2 c 25 mL). The organic phase was evaporated under reduced pressure and was further dried under high vacuum to give the title compound as a beige solid (376 mg, 72.9% yield), which was directly used for the next reaction without further purification. MS (ESI) m/z 186.0507 [M + H]+. 1H NMR (500 MHz, Chloroform-d) d 8.5 (d, J = 2.51 Hz, 1H), 8.3 (d, J = 2.55 Hz, 1H), 4.7 – 4.7 (m, 2H), 2.1 (s, 3H)).
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