13301-04-7, The chemical industry reduces the impact on the environment during synthesis 13301-04-7, name is Methyl 3,6-dibromopyrazine-2-carboxylate, I believe this compound will play a more active role in future production and life.
To a solution of methyl 3,6-dibromopyrazine-2-carboxylate (583 mg, 1.97 mmol), and (2,3-dichlorophenyl)boronic acid (375 mg, 1.97 mmol) in dioxane (40 ml) was added CS2CO3 (1.93 g, 5.91 mmol) in H2O (10 mL) and PdCkdppf (144 mg, 0.2 mmol). The reaction was refluxed for 20 min, allowed to cool to rt, and extracted with EtOAc. The combined organic layers were washed with brine and dried over MgS04. The mixture was concentrated under reduced pressure. Purification by flash chromatography resulted in 370 mg (52%) of the desired product. NMR (500 MHz, CDCh) delta 8.58 – 8.53 (m, 1H), 7.38 – 7.32 (m, 1H), 7.29 – 7.22 (m, 1H), 7.14 – 7.08 (m, 1H), 3.82 – 3.76 (m, 3H).
The chemical industry reduces the impact on the environment during synthesis Methyl 3,6-dibromopyrazine-2-carboxylate. I believe this compound will play a more active role in future production and life.
Reference:
Patent; REVOLUTION MEDICINES, INC.; LI, Jie Jack; KOLTUN, Elena S.; GILL, Adrian Liam; BUCKL, Andreas; WON, Walter; AAY, Naing; MELLEM, Kevin; TZITZILONIS, Christos; JOGALEKAR, Ashutosh; CREGG, James Joseph; (177 pag.)WO2019/75265; (2019); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem