In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 23611-75-8, name is Methyl 6-chloropyrazine-2-carboxylate belongs to pyrazines compound, it is a common compound, a new synthetic route is introduced below. Product Details of 23611-75-8
Step 1. Methyl 6-(5-chloro-l-[f4-methylphenyl)sulfonyll-lH-pyrrolo[2 -&]pYridin-3-Yl}- pyrazine-2-carboxylateA solution of methyl 6-chloropyrazine-2-carboxylate (0.1 g, 0.579 mmol), 5- chloro- 1 -[(4-methylphenyl)sulfonyl]-3-(4s4,5,5-tetramethyl- 1 ,3,2-dioxaborolan-2-yl)- 1H- pyrrolo[2,3-&]pyridine (0.276 g, 0.637 mmol), PdCl2(dppf) (0.085 g, 0.116 mmol) and Na2C(¾(0.87 mL, 2 M in water, 1.74 mmol) in DMF (6 mL) was microwaved at 130 C for 20 min. The reaction mixture was concentrated in vacuo and the residue was partitioned between ethyl acetate and water. The organic layer was then washed with 1/2 brine and brine before dried over sodium sulfate, filtered and concentrated in vacuo. The crude product was purified by silica gel chromatography, eluting with a gradient of ethyl acetate: hexane 10:90 to 80:20 to afford the title compound. MS APCI: [M + H]+ m/z = 443.0.
The synthetic route of 23611-75-8 has been constantly updated, and we look forward to future research findings.