Electric Literature of 23611-75-8, These common heterocyclic compound, 23611-75-8, name is Methyl 6-chloropyrazine-2-carboxylate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Example 12; 6-((3aR,6aS)-hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl)-N-(2-methylbenzyl)pyrazine-2-carboxamide; Example 12A; 6-Chloro-pyrazine-2-carboxylic Acid 2-methyl-benzylamide; The product from Example 1E (1.00 g, 5.79 mmol) and MgCl2 (1.11 g, 11.7 mmol) were suspended in THF (25 mL) and stirred at ambient temperature for 5 min. 2-Methylbenzylamine (1.8 mL, 14.5 mmol) was added, and the reaction was stirred at ambient temperature for 16 h. The reaction mixture was diluted with water (150 mL) and extracted with CH2Cl2 (4×100 mL). The organic extracts were combined and washed with 0.25M HCl (aq) (100 mL) and brine (100 mL), dried over Na2SO4, filtered and concentrated under vacuum. The residue was purified by silica gel chromatography to afford the title compound as a white solid (1.35 g, 89%). 1H NMR (DMSO-d6, 300 MHz) delta ppm 2.33 (s, 3H), 4.48 (d, J=6.10 Hz, 2H), 7.12-7.26 (m, 4H), 9.02 (s, 1H), 9.15 (s, 1H) 9.33 (t, J=5.76, 1H). MS (DCI/NH3) m/z 262 (M+H)+.
The synthetic route of 23611-75-8 has been constantly updated, and we look forward to future research findings.