Related Products of 14508-49-7, These common heterocyclic compound, 14508-49-7, name is 2-Chloropyrazine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Step A: Preparation of (4-(Pyrazin-2-yl)phenyI)methanol.A mixture of 2-chloropyrazme (0.230 ml, 2.62 mmol), 4-(hydroxymethyl)phenylboronic acid (517 mg, 3.41 mmol), tetrakis(t?phenylphosphine)palladium (0) (303 mg, 0.262 mmol) and 2 M potassium phosphate aqueous solution (2.62 ml, 5.24 mmol) in dioxane (10 mL) was heated at 80 0C overnight under nitrogen. The mixture was cooled down, poured into water and extracted with ethyl acetate. The combined organic layers were dried and concentrated. The residue was purified by preparative HPLC to give the title compound (350 mg) as an off-white solid. LCMS m/z = 187.0 [M+H]+. 1H NMR (400 MHz, CDCl3) delta 4.79 (s, 2H), 7.52 (d, J= 8.1 Hz, 2H), 8.02 (d, J = 8.1 Hz, 2H), 8.51 (d, J= 2.5 Hz, IH), 8.63 (dd, J = 2.4 and 1.6 Hz, IH), 9.03 (d, J= 1.6 Hz, IH).
Statistics shows that 2-Chloropyrazine is playing an increasingly important role. we look forward to future research findings about 14508-49-7.