Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 21279-64-1, name is 5-Chloropyrazine-2-carboxamide, A new synthetic method of this compound is introduced below., Application In Synthesis of 5-Chloropyrazine-2-carboxamide
15 g (95.2 mmol) of 5-chloropyrazine-2-carboxamide,24.8 g (114.2 mmol) of 3-methoxy-4-hydroxybenzyl bromide,475.8 ml of DMF,33 g (238.7 mmol) of potassium carbonate were added sequentially to a 1-liter four-necked reaction flask,The reaction was carried out at 80 C for 6 hours,After the reaction is completed, the heating is stopped,Stirring was continued overnight (TLC detection, developing solvent: ethyl acetate: n-hexane = 1: 1)And then filtered to remove insoluble matter,The filtrate was transferred to a 2-liter reaction flask,To the filtrate was added 960 ml of water,Stirring under ice bath for about 3 hours crystallization, filtration, filter cake washed with 50 ml of X2 water,The filter cake was dried at 45 C,To give 24.8 g of a pale yellow solid (yield: 75.5%, purity: 97.6%).
The synthetic route of 21279-64-1 has been constantly updated, and we look forward to future research findings.