Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 41110-33-2, name is Methyl 5-methylpyrazine-2-carboxylate, A new synthetic method of this compound is introduced below., COA of Formula: C7H8N2O2
Synthesis Example 13-2: Synthesis of 5-bromomethyl-2-methoxy carbonyl pyrazine (Compound IV-3) 500 mg of the compound obtained in Synthesis Example 13-1 was dissolved in 10 ml of carbon tetrachloride, and then 585 mg of N-bromosuccinimide and 54 mg of azobisisobutyronitrile were added to the solution. After the solution was stirred in oil bath for 20 hours at 70C, the reaction solution was filtrated, and then the filtrate was then concentrated. The resulting residue was purified by means of silica gel column chromatography (14 g, chloroform/ethyl acetate= 2/1), and 328.7mg of the above-mentioned compound was obtained as light-yellow syrup. MS(EI,Pos.):m/z=229,231[M+1]+ 1H-NMR(500MHz,DMSO-d6): delta=4.06 (3H,s), 4.62 (2H,s), 8.83 (1H,d,J=1. 5Hz), 9.26 (1H,d,J=1.5Hz).
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.