In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 944709-42-6 as follows. Recommanded Product: 944709-42-6
Into a flask under an. inert atmosphere of N2, were placed 6,8-dibromo-[1,2,4]triazolo[1,5-a]pyrazine (6.0 g, 21.6mmol) and bis(triphenylphosphine)palladium(II) dichloride (1.5 g, 2.2 mmol). To this was added the zinc reagent from Step A, and the mixture was stirred at RT for 16 h. The mixture was quenched by the addition of sat. aq. NH4C1 (200 mL), and extracted with EtOAc (3 x 100 mL). The combined organic layer was dried over anhydr. Na2SO4, filtered and the filtrate was concentrated in vacuo to dryness. The residue was purified by column chromatography withEtOAc/petroleum ether (1/5) to afford the title compound.
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