Reference of 768-05-8, These common heterocyclic compound, 768-05-8, name is Pyrazinoic acid hydrazide, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Compound 5a (150 mg, 515.87 [mu] mol)And pyrazinohydrazide (75.06 mg, 515.87 [mu] mol) were added to the reaction flask,Add 2 mL of ethanol,Room temperature reaction,TLC monitoring reaction was carried out.After the reaction,There is a lot of solid precipitation.Direct suction filter,Get cake.The cake was dried in an oven at 60 C for 6 h to obtain pure compound 6j.Yellow solid.Yield 90%.
Statistics shows that Pyrazinoic acid hydrazide is playing an increasingly important role. we look forward to future research findings about 768-05-8.