Some common heterocyclic compound, 113305-94-5, name is 5-Aminopyrazine-2-carbonitrile, molecular formula is C5H4N4, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 113305-94-5
EXAMPLE 1E N-(2-{[tert-butyl(dimethyl)silyl]oxy}-5-chlorophenyl)-N’-(5-cyano-2-pyrazinyl)urea A mixture of Example 1B (0.84 g, 7 mmol) and Example 1D (2.0 g, 7.06 mmol) in toluene (20 mL) was heated to reflux for 48 hours, cooled to room temperature, and filtered. The filter cake was washed with hexanes (2*10 mL) to provide 1.66 g (58.5%) of the desired product. MS (ESI(-)) m/z 402 (M-H)-; 1H NMR (500 MHz, DMSO-d6) delta 10.99 (s, 1H), 9.33 (s, 1H), 9.00 (d, J=1.3 Hz, 1H), 8.82 (d, J=1.36 Hz, 1H), 8.07 (d, J=2.7 Hz, 1H), 7.07 (dd, J=2.7 and 8.8 Hz, 1H), 6.97 (d, J=2.71 Hz, 1H), 0.98 (s, 9H), 0.32 (s, 6H).
The chemical industry reduces the impact on the environment during synthesis 5-Aminopyrazine-2-carbonitrile. I believe this compound will play a more active role in future production and life.
Reference:
Patent; Li, Goaquan; Li, Qun; Li, Tongmei; Lin, Nan-Horng; Mantei, Robert A.; Sham, Hing L.; Wang, Gary T.; US2004/34038; (2004); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem