Statistics shows that 2-Amino-5-bromopyrazine is playing an increasingly important role. we look forward to future research findings about 59489-71-3.
Synthetic Route of 59489-71-3, These common heterocyclic compound, 59489-71-3, name is 2-Amino-5-bromopyrazine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
C. 5-(4-(Triisopropylsilyloxy)phenyl)pyrazin-2-amine. Triisopropyl(4-(4,4,5, 5-tetramethyl-l,3,2-dioxaborolan-2-yl)phenoxy)silane (1.1 g, 2.9 mmol), 5- bromopyrazin-2-amine (507 mg, 2.9 mmol), dichloro[l,l’- EPO bis(diphenylphosphino)ferrocene]palladium(II) dichloromethane adduct (64 mg, 0.087 mmol), IM sodium carbonate (8.7 mL, 8.7 mmol), and dioxane (10 mL) were heated in a Biotage Emrys Optimizer microwave reactor at 120 C for 10 min. The reaction was extracted with water and ethyl acetate. The organic layer was dried over magnesium sulfate, filtered and concentrated. The resulting residue was purified using Biotage silica gel chromatography (0-100% ethyl acetate in hexanes) to give a tan solid (0.8 g, 80 % yield). 1H NMR (400 MHz, DMSCW6) delta 8.42 (s, IH), 7.92 (s, IH), 7.80 (d, J=8.6, 2H), 6.90 (d, J=8.6, 2H), 6.45 (s, 2H), 1.26 (q, J=IA, 7.2, 3H), 1.08 (d, J=7.4, 18H); MS (ESI) m/z 344.4 – [M+l]+.
Statistics shows that 2-Amino-5-bromopyrazine is playing an increasingly important role. we look forward to future research findings about 59489-71-3.