These common heterocyclic compound, 108-50-9, name is 2,6-Dimethylpyrazine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. HPLC of Formula: C6H8N2
EXAMPLE 29 2-Sulfonylmethyl-6-methylpyrazine sodium salt (2900) A mixture of 5.4 g of 2,6-dimethylpyrazine and 8.9 g of N-bromosuccinimide in 200 ml of carbon tetrachloride was heated to 75 and 6.1 g of dibenzoyl peroxide added. It was refluxed 6 hours, cooled, filtered and the filtrate concentrated. To this concentrate was added 10 g sodium sulfite/100 ml water and the mixture refluxed for 4 days. This aqueous solution was then continuously extracted overnight with chloroform, freeze-dried and the resultant solid taken up in 250 ml of methanol. It was filtered, the filtrate concentrated and chromatographed (Biogel P-2/water) to give 4.8 g of product (2900). It was recrystallized from ethanol/water, m.p. 282-5 (dec.). UV H2 O max: 208 (3.80), 276 (3.88).
The synthetic route of 2,6-Dimethylpyrazine has been constantly updated, and we look forward to future research findings.