Synthetic Route of 14667-55-1, A common heterocyclic compound, 14667-55-1, name is 2,3,5-Trimethylpyrazine, molecular formula is C7H10N2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
AgNO3 (34.2 mg, 0.2 mmol), tpyz (38 ml, 0.2 mmol) and H2L(313.6 mg, 0.2 mmol) were took place in CH3CN-DMF (N,Ndimethylformamide)mixed solvent (6 ml, v/v: 3/3) under stirring.Then, ammonia (14 M, 10 d) was dropped into the mixture to give aclear solution under ultrasonic treatment (160 W, 40 KHz, 30 min) atroom temperature. The resultant solution was allowed to evaporateslowly in darkness at room temperature for several days to giveirregular-yellow crystals of 1 (Yield: 32%, based on Ag). Anal. Calc.(found) for Ag2C17H23N2O4: C, 38.10 (38.16); H, 4.50 (4.33); O,11.86 (11.96); N, 5.32 (5.24) %. IR (KBr): nu(cm -1) = 3425 (s), 2977(m), 2887 (w), 2175 (w), 1653 (m), 1545 (s), 1463 (m), 1392 (s),1363 (s), 1322 (m), 1288 (m), 1207(w), 1170 (w), 1126 (w), 1085(w), 997 (w), 919 (w), 804 (m), 628 (s).
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.