Electric Literature of 5049-61-6, These common heterocyclic compound, 5049-61-6, name is Pyrazin-2-amine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
2-Amino-5-bromopyrazine (15).; To a cooled solution of 2-aminopyrazine 11 (2.00 g, 21.00 mmol) in dichloromethane (50 mL) N-bromosuccinimide (NBS) (3.73 g, 21.00 mmol) was added in portion. The mixture was stirred at 0 0C for 2h and washed with Na2CO3 s.s. and water, the organic layer was dried over Na2SO4, filtered and the solvent removed under reduced pressure to get 2.80 g of the title compound 15 (77% yield) as an orange solid without further purification (mp 105-110 0C). 1H-NMR (CDCl3): 4.61 (br s, 2H), 7.75 (s, IH), 8.07 (s, IH). MS (GC-MS): m/z 174 .
Statistics shows that Pyrazin-2-amine is playing an increasingly important role. we look forward to future research findings about 5049-61-6.