Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 5521-55-1, name is 5-Methylpyrazine-2-carboxylic acid, This compound has unique chemical properties. The synthetic route is as follows., name: 5-Methylpyrazine-2-carboxylic acid
HATU (109 mg, 0.0.29 mmol) was added to a solution of 6-(2-(trifluoromethyl)phenyl)imidazo[1,2-b]pyridazin-3-amine (50.0 mg, 0.18 mmol), 5-methylpyrazine-2-carboxylic acid (37.0 mg, 0.27 mmol), and DIEA (78 mul, 0.44 mmol) in DMAC (7 mL) The mixture was stirred at 60 C for 3 h. H2O (45 mL) was added and the resulting ppt was collected by filtration, rinsed with H2O, and dried under vacuum. The crude residue was purified by MPLC eluting with CH2Cl2/MeOH (0-5%). The product was further purified by recrystallization from CH3CN to give 5-methyl-N-(6-(2-(trifluoromethyl)phenyl)imidazo[1,2-b]pyridazin-3-yl)pyrazine-2-carboxamide (55.0 mg, 77% yield). MS (ESI) calcd for C19H13F3N6O (m/z): 398.11; found: 399 [M+H].
According to the analysis of related databases, 5521-55-1, the application of this compound in the production field has become more and more popular.
Reference:
Patent; GlaxoSmithKline LLC; CASAUBON, Rebecca, L.; NARAYAN, Radha; OALMANN, Christopher; VU, Chi, B.; (583 pag.)EP2768509; (2017); B1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem