Electric Literature of 193966-70-0, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 193966-70-0, name is Methyl 5-(bromomethyl)pyrazine-2-carboxylate belongs to Pyrazines compound, it is a common compound, a new synthetic route is introduced below.
Part B. Methyl 5-[(1-Pyrrolidinyl)methyl]pyrazine-2-carboxylate. STR471 By essentially following the procedure used to prepare Example 137, Part B, the title compound was prepared from methyl 5-(bromomethyl)pyrazine-2-carboxylate (Part A) and pyrrolidine in 85% yield as a pale yellow oil. The mixture was subjected to flash chromatography on silica gel, eluding with a gradient of EtOAc(100-95%)/Et3 N(0-5%). 1 H NMR (CDCl3) delta 9.23 (s, 1H), 8.78 (s, 1H), 4.03 (s, 3H), 3.90 (s, 2H), 2.59 (br s, 4H), 1.82 (br s, 4H).
The synthetic route of Methyl 5-(bromomethyl)pyrazine-2-carboxylate has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Eli Lilly and Company; US6025382; (2000); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem