Application of 22047-25-2, A common heterocyclic compound, 22047-25-2, name is Acetylpyrazine, molecular formula is C6H6N2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
S (346 mg, 10.8mol) and morpholine (2 mL, 20 mmol) were added to a solution of 23 (664 mg, 5.4 mmol) and 24 (1 mL, 6.5 mmol) in t-BuOH (20 mL). The mixture was heated to 60 0C for 18 h. After evaporating t-BuOH, the residue was purified by column chromatography (PE/EtO Ac=I 00: 1) to give 25 (545 mg, 36 % yield).
The synthetic route of 22047-25-2 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; CALCIMEDICA INC.; VELICELEBI, Gonul; STAUDERMAN, Kenneth A.; WHITTEN, Jeffrey P.; PEI, Yazhong; CAO, Jianguo; WANG, Zhijun; ROGERS, Evan; DYCK, Brian; GREY, Jonathan; WO2010/25295; (2010); A2;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem