Reference of 113305-94-5, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 113305-94-5, name is 5-Aminopyrazine-2-carbonitrile belongs to Pyrazines compound, it is a common compound, a new synthetic route is introduced below.
5-chloro-3- (cyclohex-1-en-1-yl) -7-methoxy-6- (4-methoxyphenyl) -2-phenylpyrazolo [1, 5-a] pyrimidine (500 mg, 1.07 mmol) , 5-aminopyrazine-2-carbonitrile (257 mg, 2.15 mmol) , palladium (II) acetate (48 mg, 0.214 mmol) , xantphos (124 mg, 0.214 mmol) and sodium carbonate (230 mg, 0.215 mmol) in 1, 4-dioxane (10 mL) under heating at 110 for 4 hours under nitrogen atmosphere. LC-MS: m/z 530.2 (M+H) +.
The synthetic route of 5-Aminopyrazine-2-carbonitrile has been constantly updated, and we look forward to future research findings.
Reference:
Patent; AGIOS PHARMACEUTICALS, INC.; TRAVINS, Jeremy, M.; KONTEATIS, Zenon, D.; SUI, Zhihua; YE, Zhixiong; (199 pag.)WO2018/39972; (2018); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem