Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 138588-41-7, name is Pyrazine-2-carboximidamide hydrochloride, A new synthetic method of this compound is introduced below., Application In Synthesis of Pyrazine-2-carboximidamide hydrochloride
[0106] A mixture of diethyl 2-(2,4,6-trifluorophenyl)malonate (250 mg, 0.861 mmol), 2- pyrazinecarboxamidine hydrochloride (144 mg, 0.904 mmol, 1.05 equiv), and tributylamine (221 mu., [172 mg], 1.08 equiv) was stirred under nitrogen atmosphere at 180 C for 1 h in a sealed tube. The mixture was cooled to room temperature and treated with 1.0 N hydrochloric acid. The precipitates were collected by filtration, washed with water and dried to give 2-pyrazin-2-yl-5- (2,4,6-trifluorophenyl)pyrimidine-4,6-diol as a dark tan solid (163 mg), which was used directly in the next step. [0107] A mixture of 2-pyrazin-2-yl-5-(2,4,6-trifluorophenyl)pyrimidine-4,6-diol (163 mg) in phosphorous oxychloride (2.03 mL, 21.9 mmol, 43 equiv) and 2,6-lutidine (404 muIota_,, 3.51 mmol, 6.9 equiv) was heated at 1 10 C for 16 h in a sealed tube. The excess phosphorous oxychloride was removed in vacuo, and the resulting residue was dissolved in ethyl acetate. The organic layer was washed with water and saturated sodium chloride, dried over sodium sulfate, and concentrated. The residue was purified by silica gel chromatography over silica gel, eluting with a gradient of 20% ethyl acetate in hexanes to 33% ethyl acetate in hexanes. Concentration provided 104 mg of the title compound as a light yellow solid (32% over two steps). -NMR (500 MHz; CDC13): delta 9.73 (s, 1H), 8.84 (s, 1H), 8.77 (s, 1H), 6.88-6.84 (m, 2H) ppm.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA; BALLATORE, Carlo; BRUNDEN, Kurt, R.; HOYE, Adam, T.; LEE, Virginia, M.y.; SMITH, Amos, B.; TROJANOWSKI, John, Q.; WO2014/47257; (2014); A2;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem