Adding a certain compound to certain chemical reactions, such as: 27398-39-6, name is 3-Chloropyrazine-2-carboxylic acid, belongs to Pyrazines compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 27398-39-6, SDS of cas: 27398-39-6
[00131] A solution of 9 (119 mg, 0.657 mmols, 1.5 eq), Al (100 g, 0.438 mmols, 1.0 eq), HATU (333 mg, 0.876 mmols, 2.0 eq) and DIPEA (170 mg, 1.31 mmols, 3.0 eq) in DMF (10 mL) was stirred at 25 ¡ãC overnight under nitrogen. The mixture was diluted with water and extracted with ethyl acetate. The combined organic extracts were washed with brine, dried over Na2504, filtered and concentrated. The residue was purified by Preparative-TLC (Petroleum ether/ethyl acetate, 2/1) to give the desired product Coupling Product B (120 mg, 0.307 mmols, 69.8percent) as a white solid.[00132] LCMS: ESI-MS: m/z: 392.2 [M+H1 RT = 2.04 mm. (Method A) [00133] HPLC: RT = 10.53 mm. [00134] ?H NMR (500 MHz, DMSO-d6): oe 8.11 (dd, 1H, Ji = 5.0Hz, J2 = 1.0Hz), 7.82 (brs, 1H), 7.58 (dd, 1H, Ji = 7.0Hz, J2 = 1.5Hz), 7.38 (d, 1H, J = 2.5Hz), 7.30 – 7.25 (m, 5H), 7.19 (t, 1H, J = 6.5Hz), 7.08 (t, 1H, J = 6.0Hz), 6.62 (dd, 1H, Ji = 7.0Hz, J2 = 5.0Hz), 4.57 (d, 2H, J= 5.5Hz), 3.74 (s, 2H), 1.26 (s, 6H) ppm.[00135] The same General Procedure B can be used to couple other combinations of amines and carboxylic acids to form the corresponding amides.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-Chloropyrazine-2-carboxylic acid, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; ALPHARMAGEN, LLC; PUTMAN, David, G.; DASSE, Olivier; HOGENKAMP, Derk; (154 pag.)WO2016/144792; (2016); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem