Some common heterocyclic compound, 27825-20-3, name is Methyl 3-Hydroxy-2-pyrazinecarboxylate, molecular formula is C6H6N2O3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 27825-20-3
EXAMPLE 19 In 5 mL of dimethyl sulfoxide is dissolved 0.42 g of L-alanyl-L-alanine trifluoroacetate. Then, 1.07 mL of triethylamine and 0.71 g of methyl 3-hydroxy-2-pyrazinecarboxylate are successively added to the solution, which is then stirred at 40 C. for 17 hours. The solvent is distilled off under reduced pressure, and 2 mL of water was added to the residue thus obtained. The deposited product is collected by filtration and purified by column chromatography [eluent: chloroform:methanol =30:1) to obtain 0.035 g of (2S)-2-[((2S)-2-{[(3-oxo-3,4-dihydro-2-pyrazinyl)carbonyl]amino}-propanoyl)amino]propanoic acid. IR(KBr) cm-1: 1665, 1675, 1655 NMR(DMSO-d6) delta value: 1.28(3H,d,J=7 Hz), 1.32(3H,d,J=7 Hz), 3.95-4.95(2H,m), 5.1(2H,brs), 7.71(1H,d,J=3 Hz), 7.87(1H,d,J=3 Hz), 8.32(1H,d,J=7 Hz), 9.9(1H,brs)
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 27825-20-3, its application will become more common.
Reference:
Patent; Furuta, Yousuke; Egawa, Hiroyuki; Nomura, Nobuhiko; US2002/13316; (2002); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem