Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 6863-73-6, name is 3-Chloropyrazin-2-amine, A new synthetic method of this compound is introduced below., Recommanded Product: 6863-73-6
N. 1 -IMIDAZO[ 1 ,2-A]PYRAZIN-8-YL-3 -TRIFLUOROMETHYL- IH-P YRAZOLE-4-C ARBOXYLIC ACID (I -P YRIDIN-3 -YL-CYCLOHEXYLMETHYL)-AMIDE (COMPOUND 14); Step 1. 8-Chloro-imidazol[l,2-a]pyrazine; HBr (48% in H2O) is added to a solution of 2-amino-3-chloropyrazine (1.2 g, 9.26 mmol) and BrCH2CH(OEt)2 (1.6 mL, 10 mmol) in MeOH and H2O (5 mL and 10 mL) at RT. The mixture is stirred for 24 h at RT and then heated to 40 C for 48 h. The pH is adjusted to 7 with sat. Na2Ctheta3. The mixture is extracted with CH2Cl2. The organic phase is dried over anhydrous Na2SO^ The product is purified by silica gel column chromatography (4%MeOH in CH2Cl2) to give the title compound as an off white solid.
The synthetic route of 6863-73-6 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; NEUROGEN CORPORATION; WO2009/12482; (2009); A2;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem