Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 873-42-7, name is 2-Amino-3,5-dichloropyrazine, This compound has unique chemical properties. The synthetic route is as follows., Product Details of 873-42-7
In a flask, under an inert atmosphere of argon, was added 3,5-dichloropyrazin-2-amine (7.0 g, 42.7 mmol), bis(triphenylphosphine)palladium(II) dichloride (3.0 g, 4.27 mmol) and THF (240 mL). The resulting mixture was allowed to stir for 1 h at RT. The intermediate from Step A (30 mL, 64 mmol) was added and the resulting solution was warmed at 35oC for 2 days. The reaction was then quenched by the addition of brine. The resulting solution was extracted with EtOAc (3X) and the organic layers combined, washed with brine, dried over anhydr. Na2SO4, and filtered. The residue was purified by silica gel chromatography with EtOAc:petroleum ether (5-20%) to afford the title compound.
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 873-42-7.
Reference:
Patent; MERCK SHARP & DOHME CORP.; BERGER, Raphaelle; DONG, Guizhen; RAGHAVAN, Subharekha; YANG, Zhiqiang; (179 pag.)WO2017/200857; (2017); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem