Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 113305-94-5, name is 5-Aminopyrazine-2-carbonitrile, A new synthetic method of this compound is introduced below., SDS of cas: 113305-94-5
Preparation 15; -32-(E)-5-(3 -(2-Methoxy-6-(4-methoxybenzyloxy)phenyl)- 1 -(methylthio)-3 -oxoprop- 1 – enylamino)pyrazine-2-carbonitrile; To a dry, inert 22 L flask are added sodium hydride (159.2 g, 3.98 mol) and tetrahydrofuran (10.4 L). The mixture is cooled to 5 – 15 0C. 5-Isocyanopyrazin-2- amine (382.2 g, 3.18 mol) is added in four portions over 30 min to control the release of hydrogen, allowing foaming to subside between additions and maintaining the temperature at 10 0C. The mixture is stirred for 15 – 90 min while allowing the temperature to increase to 15 0C. To the reaction mixture is charged with l-(2-methoxy- 6-(4-methoxybenzyloxy)phenyl)-3,3-bis(methylthio)prop-2-en-l-one (1036 g, 2.65 mol) in portions to control foaming. The resulting slurry is stirred for 15 min. The mixture is heated to a gentle reflux at 66 0C. The reaction conversion is monitored by HPLC. The reaction mixture is quenched into chilled water (14.2 L) followed by extractive work up with ethyl acetate. The organic portion is concentrated to form a slurry which is filtered to provide 957 g (78%) of the title compound, mp 128 – 135 0C; ES/MS m/z 463.2
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; ELI LILLY AND COMPANY; FAROUZ, Francine, S.; HOLCOMB, Ryan, Coatsworth; KASAR, Ramesh; MYERS, Steven, Scott; WO2010/77758; (2010); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem