A common compound: 5521-58-4, name is 5-Methylpyrazin-2-amine, belongs to Pyrazines compound, it can change the direction of chemical reaction, and react with certain compounds to generate new functional products. A new synthetic method of this compound is introduced below. 5521-58-4
1-Chloro-N,N,2-trimethyl-l-propenylamine (0.86 g, 6.56 mmol) was added to a solution of 3- [4-(azetidin-1-ylcarbonyl)-2-fluorophenoxy]-5-(( 15)-2- {(tert-butyl( dimethyl)silyl]oxy} -1- methylethoxy)benzoic acid (3 g, 5.96 mmol) in DCM (100 mL) and stirred at RT for Ihour. 2- Amino-5-methylpyrazine (1.3 g, 11.9 mmol) and pyridine (0.94 mL, 11.9 mmol) were added and the reaction stirred for a further 30 mins. The solvent was removed in vacuo. Water (100 mL) was added and the mixture extracted with ethyl acetate (3 x 50 mL). The extracts were combined and washed with water (100 mL), brine (100 mL), dried (MgS04), filtered, and evaporated in vacuo to give the crude product which was chromatographed on silica, eluting with a gradient of 50-100% ethyl acetate in isohexane, to give the desired compound (3.6 g). ?H NMR No. (CDC13): 0.00 (s, 3H), 0.03 (s, 3H), 0.81 (s, 9H), 1.30 (d, 3H), 2.32 (quin, 2H), 2.51 (s, 3H), 3.60-3.80 (m, 2H), 4.20-4.39 (brm, 4H), 4.45 (m, 1H), 6.75 (m, 1H), 7.03 (d, 2H), 7.21 (s, 1 H), 7.40 (d, 1 H), 7.50 (d, 1 H), 8.10 (s, 1 H), 8.27 (s, 1 H), 9.48 (s, 1 H). m/z 595 (M+H)+
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 5521-58-4, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2005/121110; (2005); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem