Adding a certain compound to certain chemical reactions, such as: 21943-17-9, name is 5-Bromo-3-chloropyrazin-2(1H)-one, belongs to Pyrazines compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 21943-17-9, Recommanded Product: 5-Bromo-3-chloropyrazin-2(1H)-one
4.3.20 3,5-Bis-(4-methoxyphenyl)-1H-pyrazin-2-one 57 A solution of 56 (50.6 mg, 0.242 mmol), sodium carbonate (35.6 mg, 0.336 mmol), 4-methoxyphenylboronic acid (182 mg, 1.20 mmol) and tetrakis(triphenylphosphine)palladium (0) (17 mg, 0.015 mmol) in water (0.7 mL) and acetonitrile (2.7 mL) was heated in a microwave reactor using variable wattage to 150 C for 20 min. The mixture was partitioned between ethyl acetate (50 mL) and water (40 mL). The organic layer was filtered through a plug of silica gel (6 g). The filtrate was concentrated and purified by flash column chromatography on silica, eluting with ethyl acetate to give 57 (73 mg, 47%). Mp >300 C; Rf (EtOAc) 0.16; numax (thin film/cm-1) 3019 (Ar CH), 1653 (C=O), 972 (C-O), 929 (C–O); deltaH (500 MHz; CD3OD) 3.85 (3H, s, OCH3), 3.88 (3H, s, OCH3), 7.01 (2H, d, J 8.0 Hz, ArH), 7.02 (2H, d, J 9.0 Hz, ArH), 7.66 (1H, s, 6-H), 7.86 (2H, d, J 8.0 Hz, ArH), 8.46 (2H, d, J 9.0 Hz, ArH); LC-MS (6 min) m/z 309 (MH+); HPLC tR 4.11 min; purity 99%; HRMS (found: m/z 309.1243; C18H17N2O3 requires 309.1234).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 5-Bromo-3-chloropyrazin-2(1H)-one, other downstream synthetic routes, hurry up and to see.
Reference:
Article; Caldwell, John J.; Veillard, Nicolas; Collins, Ian; Tetrahedron; vol. 68; 47; (2012); p. 9713 – 9728,16;; ; Article; Caldwell, John J.; Veillard, Nicolas; Collins, Ian; Tetrahedron; vol. 68; 47; (2012); p. 9713 – 9728;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem